- Sabel
- Sable
- Sabo
- Sadler
- Saiyavong
- Salery
- Salley
- Salminen
- Saloom
- Salter
- Samford
- Sample
- Sampson
- Sams
- Samuel
- Sanders
- Sanderson
- Sanford
- Sankey
- Sansom
- Sasser
- Savage
- Sawyer
- Saxman
- Scales
- Scarbrough
- Schachte
- Schaefer
- Schaffer
- Schafrik
- Schaum
- Scheeren
- Scheetz
- Schlechty
- Schmidt
- Schneider
- Schofield
- Schoudel
- Schroering
- Schroll
- Schultz
- Schwalbe
- Schwalen
- Scoggan
- Scoggin
- Scott
- Seaborn
- Seabrook
- Seagraves
- Seale
- Seales
- Sealy
- Seamon
- Searcy
- Sears
- Seay
- Sebring
- Segraves
- Segrest
- Sehgal
- Seiberling
- Sellers
- Semler
- Senderson
- Senn
- Sevier
- Seward
- Sewell
- Sexton
- Seymour
- Shaddix
- Shaffer
- Shah
- Shamburger
- Shanahan
- Shannon
- Sharit
- Sharker
- Sharp
- Sharpe
- Sharpless
- Shashy
- Shaw
- Shedrick
- Shell
- Shellhorn
- Shelton
- Shepard
- Shepherd
- Shepler
- Sheppard
- Sherbett
- Sherlin
- Sherlock
- Sherman
- Shields
- Shifferd
- Shipman
- Shippey
- Shoals
- Shoemaker
- Shoup
- Shubird
- Shufford
- Shuford
- Shults
- Siddiqui
- Sides
- Sikes
- Siler
- Sillman
- Silverman
- Simmons
- Simms
- Simon
- Simpler
- Simpson
- Sims
- Singletary
- Singleton
- Sipper
- Sippial
- Sistrunk
- Skanes
- Skelton
- Skinner
- Skipper
- Skoneki
- Slate
- Slaten
- Slater
- Slaughter
- Slawson
- Slayman
- Sledge
- Sloan
- Sloane
- Small
- Smart
- Smiley
- Smilie
- Smith
- Smitherman
- Smyth
- Snellgrove
- Snider
- Snipes
- Snow
- Snyder
- Songer
- Sorrells
- Soukhamneuth
- Southall
- Sowell
- Spain
- Sparks
- Speaks
- Spear
- Spears
- Speight
- Spencer
- Spiers
- Spivey
- Spriggs
- Springall
- Springer
- Spurlin
- Stabler
- Stacks
- Stafford
- Stakely
- Staley
- Stallings
- Stallworth
- Stanfield
- Stanford
- Stankard
- Stanley
- Stanton
- Stark
- Starks
- Staub
- Steele
- Steffan
- Stein
- Steindorff
- Steiner
- Stelk
- Stephens
- Stephenson
- Sterling
- Stevens
- Stevenson
- Stever
- Stewart
- Stickle
- Stillings
- Stinson
- Stjohn
- Stockman
- Stoddard
- Stojak
- Stokes
- Stolarczyk
- Stone
- Stoudemire
- Stough
- Stovall
- Stover
- Stowers
- Strachan
- Stratton
- Straughn
- Strawbridge
- Streeter
- Streetman
- Strength
- Strickland
- Strickler
- Stricklin
- Stringer
- Stroh
- Stronach
- Strong
- Stroud
- Struggs
- Struthers
- Stuart
- Stubbskemp
- Stuckey
- Stutheit
- Styron
- Suchdeva
- Suddith
- Suhr
- Sullen
- Sullivan
- Summerford
- Summerlin
- Sumner
- Sunderman
- Sutherland
- Sutter
- Suttle
- Suttles
- Sutton
- Swafford
- Swain
- Swan
- Swanner
- Sweeney
- Sweezey
- Swift
- Sykes
- Sylvester